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HomeProduct name list1,2-NAPHTHOQUINONE

1,2-NAPHTHOQUINONE

Synonym(s):β-Naphthoquinone

  • CAS NO.:524-42-5
  • Empirical Formula: C10H6O2
  • Molecular Weight: 158.15
  • MDL number: MFCD00001698
  • EINECS: 208-360-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 16:21:11
1,2-NAPHTHOQUINONE Structural

What is 1,2-NAPHTHOQUINONE?

Chemical properties

brown powder

The Uses of 1,2-NAPHTHOQUINONE

Chemical reagent and intermediate.

The Uses of 1,2-NAPHTHOQUINONE

1,2-Naphthoquinone was employed as mediator during electrochemical mapping of redox activity in normal human breast (MCF-10A) cells by scanning electrochemical microscopy (SECM).

The Uses of 1,2-NAPHTHOQUINONE

1,2-Naphthquinone is a highly reactive quinone species which aids in modulating cellular homeostasis and electrophilic signal transduction pathways.

Definition

ChEBI: 1,2-naphthoquinone is the parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles. It has a role as a carcinogenic agent and an aryl hydrocarbon receptor agonist. It derives from a hydride of a naphthalene.

What are the applications of Application

1,2-Naphthoquinone is a useful naphthalene for proteomics research

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 603, 1984 DOI: 10.1016/S0040-4039(00)99949-0
The Journal of Organic Chemistry, 51, p. 5390, 1986 DOI: 10.1021/jo00376a061

General Description

Golden yellow needles or brown powder. Decomposes to a bluish-black color on standing.

Air & Water Reactions

The neat chemical may be sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

Ketones, such as 1,2-NAPHTHOQUINONE, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Hazard

Irritant

Health Hazard

ACUTE/CHRONIC HAZARDS: 1,2-NAPHTHOQUINONE is an irritant. When heated to decomposition it emits acrid smoke and fumes.

Fire Hazard

Flash point data for 1,2-NAPHTHOQUINONE are not available. 1,2-NAPHTHOQUINONE is probably combustible.

Purification Methods

Crystallise the quinone from ether (red needles) or *benzene (orange leaflets). [Beilstein 7 IV 2417.]

Properties of 1,2-NAPHTHOQUINONE

Melting point: 139-142 °C (dec.) (lit.)
Boiling point: 243.22°C (rough estimate)
Density  1.450 g/cm3 (25℃)
refractive index  1.5300 (estimate)
storage temp.  2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly)
form  Crystalline Mass or Waxy Solid
color  Colorless or white to pale yellow
Merck  14,6394
BRN  606546
Stability: Light Sensitive
CAS DataBase Reference 524-42-5(CAS DataBase Reference)
EPA Substance Registry System 1,2-Naphthoquinone (524-42-5)

Safety information for 1,2-NAPHTHOQUINONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1,2-NAPHTHOQUINONE

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