1,2-Bis(chloromethyl)benzene

Synonym(s):o-Xylylene dichloride;1,2-Bis(chloromethyl)benzene

white to light yellow crystal powde

1,2-Bis(chloromethyl)benzene is used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit 1 .

α,α′?Dichloro-o-xylene was used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit.

α,α′-Dichloro-o-xylene reacts with elemental tellurium and NaI in 2-methoxyethanol to form 1,1-diiodo-3,4-benzo-1-telluracyclopentane.

Poison by intravenous route. Mutation data reported. See also CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic Cl-.

Melting point:	51-55 °C (lit.)
Boiling point:	239-241 °C (lit.)
Density	1.3930
refractive index	1.5544 (estimate)
Flash point:	226 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
form	Crystals or Crystalline Powder
color	white to light beige
Water Solubility	hydrolysis
BRN	2043675
CAS DataBase Reference	612-12-4(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,2-bis(chloromethyl)-(612-12-4)
EPA Substance Registry System	1,2-Bis(chloromethyl)benzene (612-12-4)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.