11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE

Synonym(s):11β,17α-Dihydroxy-4-pregnene-3,20-dione;11β,17α-Dihydroxyprogesterone;21-Desoxycortisol;4-Pregnene-11β,17α-diol-3,20-dione

CAS NO.：641-77-0
Empirical Formula: C21H30O4
Molecular Weight: 346.46
MDL number: MFCD00056476
EINECS: 211-375-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:17

11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE Structural

What is 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE?

Chemical properties

Pale Yellow Solid

The Uses of 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE

A metabolite of Fluticasone propionate (F599500).

The Uses of 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE

21-Deoxy Cortisol (Hydrocortisone EP Impurity L) is a metabolite of Fluticasone propionate (F599500).

Definition

ChEBI: 21-deoxycortisol is a deoxycortisol that is 17xi-pregn-4-ene-3,20-dione substituted by a beta-hydroxy group at position 11 and an alpha-hydroxy group at position 17. It is a marker of virilizing adrenal hyperplasia caused by 21-hydroxylase deficiency. It has a role as a human blood serum metabolite and a mouse metabolite. It is an 11beta-hydroxy steroid, a 17alpha-hydroxy-C21-steroid, a tertiary alpha-hydroxy ketone and a deoxycortisol.

Properties of 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE

Melting point:	225-228 °C
Boiling point:	523.9±50.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
Flash point:	9℃
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	12.86±0.70(Predicted)
color	White to Pale Yellow

Safety information for 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.