11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
- CAS NO.：107615-77-0
- Empirical Formula: C20H34O5
- Molecular Weight: 354.48
- MDL number: MFCD00216071
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA?
Description
11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.2
What are the applications of Application
11β-13,14-dihydro-15-keto Prostaglandin F2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway
Definition
ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.
References
1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).
Properties of 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
| solubility | 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) |
Safety information for 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
Computed Descriptors for 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIR AMLODIPINE SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) SODIUM VALPROATE 5-Fluoro-2-iodo-3-methylaniline Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 3-Bromo-2-hydroxybenzeneacetic acid 5-Iodo-3-methyl-2-nitropyridine 1-(3-Chloro-2-hydroxyphenyl)-2-propanoneRelated products of tetrahydrofuran
You may like
-
![446292-08-6 (S)-2-{2-Oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-isoindole-1,3-dione 99](https://img.chemicalbook.in//Content/image/CP5.jpg)
446292-08-6 (S)-2-{2-Oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-isoindole-1,3-dione 99View Details
446292-08-6 -
494-19-9 >99View Details
494-19-9 -
Iminostilbene 256-96-2 98View Details
256-96-2 -
147403-52-9 > 99View Details
147403-52-9 -
5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride 120013-39-0 > 99.0View Details
120013-39-0 -
718635-93-9 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one >99%View Details
718635-93-9 -
120014-30-4 5,6-Dimethoxy-2-[(4-piperidyl) methyl]indan-1-one > 99.0View Details
120014-30-4 -
147403-65-4 > 99View Details
147403-65-4