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HomeProduct name list11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA Structural

What is 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA?

Description

11β-13,14-dihydro-15-keto PGF is a metabolite of PGD2 in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF, as the immediate product, and 11β-13,14-dihydro-15-keto PGF in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF and then to 11β-15-keto-PGF in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF, via 11β-PGF, in the presence of NAD+ and NADP+.2

What are the applications of Application

11β-13,14-dihydro-15-keto Prostaglandin F2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway

Definition

ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.

References

1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).

Properties of 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

solubility  10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)

Safety information for 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Computed Descriptors for 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

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