11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
- CAS NO.：107615-77-0
- Empirical Formula: C20H34O5
- Molecular Weight: 354.48
- MDL number: MFCD00216071
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA?
Description
11β-13,14-dihydro-15-keto PGF2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF2α.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.2
What are the applications of Application
11β-13,14-dihydro-15-keto Prostaglandin F2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway
Definition
ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.
References
1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).
Properties of 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
| solubility | 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) |
Safety information for 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
Computed Descriptors for 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
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