11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- CAS NO.:13951-70-7
- Empirical Formula: C21H28O6
- Molecular Weight: 376.44
- MDL number: MFCD00872019
- EINECS: 237-731-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 13:31:19
What is 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione?
Chemical properties
White Crystalline Solid
The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
A metabolite of Budesonide, an antiinflammatory agent
The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
A metabolite of Budesonide (B689490), an antiinflammatory agent.
The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.
What are the applications of Application
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione is a metabolite of Budesonide
Synthesis
501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).
Properties of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Melting point: | 235-238°C |
Boiling point: | 591.5±50.0 °C(Predicted) |
Density | 1.38±0.1 g/cm3(Predicted) |
vapor pressure | 0Pa at 25℃ |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
form | Solid |
pka | 11.93±0.70(Predicted) |
color | White to Light Yellow |
Water Solubility | 815mg/L at 20℃ |
CAS DataBase Reference | 13951-70-7(CAS DataBase Reference) |
Safety information for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Computed Descriptors for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Abamectin manufacturer
GLP Pharma Standards
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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