Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

  • CAS NO.:13951-70-7
  • Empirical Formula: C21H28O6
  • Molecular Weight: 376.44
  • MDL number: MFCD00872019
  • EINECS: 237-731-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 13:31:19
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Structural

What is 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione?

Chemical properties

White Crystalline Solid

The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

A metabolite of Budesonide, an antiinflammatory agent

The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

A metabolite of Budesonide (B689490), an antiinflammatory agent.

The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

What are the applications of Application

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione is a metabolite of Budesonide

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Properties of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Melting point: 235-238°C
Boiling point: 591.5±50.0 °C(Predicted)
Density  1.38±0.1 g/cm3(Predicted)
vapor pressure  0Pa at 25℃
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly, Heated)
form  Solid
pka 11.93±0.70(Predicted)
color  White to Light Yellow
Water Solubility  815mg/L at 20℃
CAS DataBase Reference 13951-70-7(CAS DataBase Reference)

Safety information for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Computed Descriptors for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.