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HomeProduct name list11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

  • CAS NO.:13951-70-7
  • Empirical Formula: C21H28O6
  • Molecular Weight: 376.44
  • MDL number: MFCD00872019
  • EINECS: 237-731-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Structural

What is 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione?

Chemical properties

White Crystalline Solid

The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

A metabolite of Budesonide, an antiinflammatory agent

The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

A metabolite of Budesonide (B689490), an antiinflammatory agent.

The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

What are the applications of Application

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione is a metabolite of Budesonide

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Properties of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Melting point: 235-238°C
Boiling point: 591.5±50.0 °C(Predicted)
Density  1.38±0.1 g/cm3(Predicted)
vapor pressure  0Pa at 25℃
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly, Heated)
form  Solid
pka 11.93±0.70(Predicted)
color  White to Light Yellow
Water Solubility  815mg/L at 20℃
CAS DataBase Reference 13951-70-7(CAS DataBase Reference)

Safety information for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Computed Descriptors for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

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