11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- CAS NO.:13951-70-7
- Empirical Formula: C21H28O6
- Molecular Weight: 376.44
- MDL number: MFCD00872019
- EINECS: 237-731-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione?
Chemical properties
White Crystalline Solid
The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
A metabolite of Budesonide, an antiinflammatory agent
The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
A metabolite of Budesonide (B689490), an antiinflammatory agent.
The Uses of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.
What are the applications of Application
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione is a metabolite of Budesonide
Synthesis
501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).
Properties of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Melting point: | 235-238°C |
Boiling point: | 591.5±50.0 °C(Predicted) |
Density | 1.38±0.1 g/cm3(Predicted) |
vapor pressure | 0Pa at 25℃ |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
form | Solid |
pka | 11.93±0.70(Predicted) |
color | White to Light Yellow |
Water Solubility | 815mg/L at 20℃ |
CAS DataBase Reference | 13951-70-7(CAS DataBase Reference) |
Safety information for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Computed Descriptors for 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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