1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE
Synonym(s):o-Phenanthroline hydrochloride monohydrate;1,10-Phenanthroline chloride monohydrate;o-Phenanthroline hydrochloride monohydrate
- CAS NO.：18851-33-7
- Empirical Formula: C12H11ClN2O
- Molecular Weight: 234.68
- MDL number: MFCD00150061
- EINECS: 627-064-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 11:59:05
What is 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE?
Description
1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1? It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.? It may be used when preparing cell lysates for enrichment of ubiquitinated proteins? which are especially sensitive to DUBs in the JAMM family.2,3
Chemical properties
White fine crystalline powder
The Uses of 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE
1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron.
References
1) Swann?et al?(1981)?Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J.,?195?41 2) Cooper?et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J.,?28?621 3) Lu?et al. (2015)?Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science,?348?200
Properties of 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE
| Melting point: | 224-225 °C(lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 0.1 g/mL, clear |
| form | Solid |
| color | Colorless crystals |
| Water Solubility | Soluble in water. |
| BRN | 4007967 |
| Stability: | Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
Safety information for 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Environment GHS09 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. |
Computed Descriptors for 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE
Abamectin manufacturer
JSK Chemicals
1Y
Phone:+919879767970
Whatsapp: +91 9879767970
product: 18851-33-7 1,10-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE 99%
Pallav Chemicals And Solvents Pvt Ltd
1Y
Phone:+91-9136093115
Whatsapp: +91- 9136093115
product: 1.10-Phenthroline Hydrochloride Monohydrate 99.5% AR 18851-33-7 99%
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