1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE

Synonym(s):o-Phenanthroline hydrochloride monohydrate;1,10-Phenanthroline chloride monohydrate;o-Phenanthroline hydrochloride monohydrate

CAS NO.：18851-33-7
Empirical Formula: C12H11ClN2O
Molecular Weight: 234.68
MDL number: MFCD00150061
EINECS: 627-064-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 11:59:05

1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Structural

What is 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE?

Description

1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1? It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.? It may be used when preparing cell lysates for enrichment of ubiquitinated proteins? which are especially sensitive to DUBs in the JAMM family.2,3

Chemical properties

White fine crystalline powder

The Uses of 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE

1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron.

References

1) Swann?et al?(1981)?Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J.,?195?41 2) Cooper?et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J.,?28?621 3) Lu?et al. (2015)?Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science,?348?200

Properties of 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE

Melting point:	224-225 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 0.1 g/mL, clear
form	Solid
color	Colorless crystals
Water Solubility	Soluble in water.
BRN	4007967
Stability:	Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Safety information for 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up.