ZPCK

Synonym(s):N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone;NSC 251810;SL-01;ZPCK

CAS NO.：26049-94-5
Empirical Formula: C18H18ClNO3
Molecular Weight: 331.79
MDL number: MFCD00037114
EINECS: 247-432-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is ZPCK?

Description

SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.

Chemical properties

white powder

The Uses of ZPCK

ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.

The Uses of ZPCK

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.

The Uses of ZPCK

Enzyme inhibitor.

References

1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450

Properties of ZPCK

Melting point:	107-108 °C(lit.)
Boiling point:	503.1±50.0 °C(Predicted)
Density	1.1630 (rough estimate)
refractive index	1.6470 (estimate)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form	solid
pka	10.74±0.46(Predicted)
color	White
optical activity	[α]23/D +30°, c = 1 in chloroform
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference	26049-94-5
EPA Substance Registry System	Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5)

Safety information for ZPCK

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.