(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
Synonym(s):(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride;NSC146109 hydrochloride;XI-011 hydrochloride
- CAS NO.：59474-01-0
- Empirical Formula: C17H17ClN2S
- Molecular Weight: 316.85
- MDL number: MFCD07783997
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE?
The Uses of (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
This molecule inhibits MDMX expression in breast cancer cells through activating p53 resulting in apoptosis in cancer cells.
What are the applications of Application
NSC 146109 hydrochloride is an antitumor activator of p53-dependent transcription
Biological Activity
Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.
Properties of (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
| storage temp. | Desiccate at RT |
| solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| form | Powder |
| color | White to yellow |
Safety information for (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
Computed Descriptors for (10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE
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