5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
- CAS NO.：56990-57-9
- Empirical Formula: C19H13N3O7S2
- Molecular Weight: 459.45
- MDL number: MFCD09971104
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-?
The Uses of 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
NSC 87877 is an inhibitor of SHP2 and SHP1 protein tyrosine phosphatases
What are the applications of Application
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases
Definition
ChEBI: 8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid.
Biological Activity
Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC 50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
storage
Store at +4°C
Properties of 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
| storage temp. | Store at +4°C |
| solubility | ≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic |
| form | Powder |
| color | Light brown to black |
Safety information for 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
Computed Descriptors for 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
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