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HomeProduct name list5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-

5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-

5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- Structural

What is 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-?

The Uses of 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-

NSC 87877 is an inhibitor of SHP2 and SHP1 protein tyrosine phosphatases

What are the applications of Application

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases

Definition

ChEBI: 8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid.

Biological Activity

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC 50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

storage

Store at +4°C

Properties of 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-

storage temp.  Store at +4°C
solubility  ≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic
form  Powder
color  Light brown to black

Safety information for 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-

Computed Descriptors for 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-

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