1-O-HEXADECYL-SN-GLYCEROL

Synonym(s):1-O-hexadecyl-sn-glycerol (HG)

CAS NO.：506-03-6
Empirical Formula: C19H40O3
Molecular Weight: 316.52
MDL number: MFCD00151171
EINECS: 208-026-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is 1-O-HEXADECYL-SN-GLYCEROL?

Description

1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E₂ (PGE₂; ) in normal human epidermal keratinocytes (NHEKs). 1-O-Hexadecyl-sn-glycerol (50 μM) increases coronary flow and left ventricular developed pressure and reduces malondialdehyde (MDA) formation ex vivo in a rat heart model of ischemia/reperfusion injury.

The Uses of 1-O-HEXADECYL-SN-GLYCEROL

1-O-Hexadecyl-sn-glycerol restores plasmalogen levels in Chinese hamster ovary (CHO) cells and human pulmonary arterial endothelial cells (PAEC). Plasmalogen may play a role in protecting animal cells against photosensitized killing.

What are the applications of Application

1-O-Hexadecyl-sn-glycerol is a naturally occuring ether lipid

Definition

ChEBI: A 1-n-hexadecyl analogue of an optically active alkylglycerol compound.

Purification Methods

Recrystallise it from hexane. [Beilstein 1 III 2322.]

Properties of 1-O-HEXADECYL-SN-GLYCEROL

Melting point:	64°
Boiling point:	bp0.005 120°
alpha	D20 +3.0° (c = 1.16 in chloroform)
Density	1.0054 (rough estimate)
refractive index	1.4410 (estimate)
storage temp.	-15°C
solubility	DMF: 16 mg/ml; DMSO: 0.16 mg/ml; Ethanol: 5 mg/ml
form	A crystalline solid
pka	13.68±0.20(Predicted)