1-Naphthyl isocyanate

CAS NO.：86-84-0
Empirical Formula: C11H7NO
Molecular Weight: 169.18
MDL number: MFCD00003814
EINECS: 201-703-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 1-Naphthyl isocyanate?

Chemical properties

colourless or slightly yellow liquid

The Uses of 1-Naphthyl isocyanate

1-Naphthyl isocyanate is used in the preparation of cationic aromatic urethane. It is useful for the study of cholangiolitic hepatotoxicity in laboratory animals. It is also employed as separate enantiomers of beta-blockers.

Synthesis Reference(s)

Synthetic Communications, 23, p. 335, 1993 DOI: 10.1080/00397919308009785

Purification Methods

Distil the isocyanate at atmospheric pressure or in a vacuum. It can be crystallised from pet ether (b 60-70o) at low temperature. It has a pungent odour, is TOXIC and is absorbed through the skin. [Beilstein 12 H 1244, 12 III 2948.]

Properties of 1-Naphthyl isocyanate

Melting point:	4 °C (lit.)
Boiling point:	267 °C/761 mmHg (lit.)
Density	1.177 g/mL at 25 °C (lit.)
vapor density	2.9 (vs air)
vapor pressure	168.8 mm Hg ( 37.7 °C)
refractive index	n20/D 1.6344(lit.)
Flash point:	-1 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Miscible with alcohol, chloroform and diethyl ether.
form	clear liquid
color	Colorless to Light yellow to Light orange
Sensitive	Moisture Sensitive
Merck	14,6410
BRN	742779
Stability:	Stable. Incompatible with strong oxidizing agents, alcohols.
CAS DataBase Reference	86-84-0(CAS DataBase Reference)
NIST Chemistry Reference	Naphthalene, 1-isocyanato-(86-84-0)
EPA Substance Registry System	1-Isocyanatonaphthalene (86-84-0)

Safety information for 1-Naphthyl isocyanate

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.