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HomeProduct name list1-METHYLURIC ACID

1-METHYLURIC ACID

Synonym(s):1-Methyl-2,6,8-trihydroxypurine;1MUA;1-U

  • CAS NO.:708-79-2
  • Empirical Formula: C6H6N4O3
  • Molecular Weight: 182.14
  • MDL number: MFCD00042987
  • EINECS: 211-905-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-03 12:26:03
1-METHYLURIC ACID Structural

What is 1-METHYLURIC ACID?

Chemical properties

White to Off-White Solid

The Uses of 1-METHYLURIC ACID

1-Methyluric acid has been used:

  • for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
  • in turbidimetric assay of synthetic urine samples
  • as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay

What are the applications of Application

1-Methyluric acid is a major metabolite of caffeine and theophylline with antioxidant activity

Definition

ChEBI: An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine.

Biochem/physiol Actions

1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.

Purification Methods

Recrystallise it from H2O. Its solubility at 17.5o is 1g in 353mL of H2O. [Bergmann & Dikstein J Am Chem Soc 77 691 1955.] It has UV: max at 231 and 283nm (pH 3), and 217.5 and 292.5nm (pH >12) [Johnson Biochem J 5 133 1952]. [Beilstein 26 II 299, 26 III/IV 2621.]

Properties of 1-METHYLURIC ACID

Melting point: >325°C
Boiling point: 315.51°C (rough estimate)
Density  1.5283 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Refrigerator
solubility  Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
form  Solid
pka 5.60±0.50(Predicted)
color  Pale Yellow to Pale Brown
Water Solubility  1.585g/L(temperature not stated)
BRN  195190

Safety information for 1-METHYLURIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P330:Rinse mouth.
P362:Take off contaminated clothing and wash before reuse.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P405:Store locked up.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.
P501:Dispose of contents/container to..…

Computed Descriptors for 1-METHYLURIC ACID

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