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HomeProduct name list1-Methyl-L-histidine

1-Methyl-L-histidine

Synonym(s):Nτ-Methyl-L-histidine;3-(1-Methylimidazol-4-yl)-L-alanine;3-Methyl-L-histidine (archaic)

  • CAS NO.:332-80-9
  • Empirical Formula: C7H11N3O2
  • Molecular Weight: 169.18
  • MDL number: MFCD00005295
  • EINECS: 206-368-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
1-Methyl-L-histidine Structural

What is 1-Methyl-L-histidine?

Chemical properties

Beige powder

The Uses of 1-Methyl-L-histidine

The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent developm ent of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

The Uses of 1-Methyl-L-histidine

The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

Definition

ChEBI: N(tele)-methyl-L-histidine is a L-histidine derivative in which the methyl group is at N(tele)-position. It has a role as a human metabolite. It is a L-histidine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a N(tele)-methyl-L-histidine zwitterion.

Properties of 1-Methyl-L-histidine

Melting point: ~240 °C (dec.) (lit.)
Boiling point: 298.47°C (rough estimate)
alpha  -24 º (c=2% in H2O)
Density  1.2509 (rough estimate)
refractive index  1.5950 (estimate)
storage temp.  2-8°C(protect from light)
solubility  Methanol (Slightly), Water (Slightly, Sonicated)
form  Solid
pka 1.69(at 25℃)
color  Off-White to Pale Beige
optical activity [α]20/D 24±1°, c = 2% in H2O
BRN  9727
Stability: Hygroscopic
CAS DataBase Reference 332-80-9(CAS DataBase Reference)

Safety information for 1-Methyl-L-histidine

Computed Descriptors for 1-Methyl-L-histidine

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