1-Hydroxybenzotriazole hydrate
Synonym(s):HOBt Hydrate
- CAS NO.：123333-53-9
- Empirical Formula: C6H7N3O2
- Molecular Weight: 153.14
- MDL number: MFCD00065690
- EINECS: 602-929-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 1-Hydroxybenzotriazole hydrate?
Chemical properties
White to off-white powder
The Uses of 1-Hydroxybenzotriazole hydrate
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
- Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
The Uses of 1-Hydroxybenzotriazole hydrate
A common additive for peptide coupling.
The Uses of 1-Hydroxybenzotriazole hydrate
additive for oligonucleotide couplings and in racemization-free peptide couplings
General Description
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
Properties of 1-Hydroxybenzotriazole hydrate
| Melting point: | 155-158 °C(lit.) |
| Boiling point: | 248.8°C (rough estimate) |
| Density | 1.065 g/cm |
| refractive index | 1.6910 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMF: 100 mg/mL, clear |
| form | Solid |
| color | White to Off-White |
| Water Solubility | slightly soluble |
| BRN | 4515 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 123333-53-9(CAS DataBase Reference) |
Safety information for 1-Hydroxybenzotriazole hydrate
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P230:Keep wetted with … P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P380+P375:in case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. P501:Dispose of contents/container to..… |
Computed Descriptors for 1-Hydroxybenzotriazole hydrate
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