1-Bromo-4-chloro-2-fluorobenzene
- CAS NO.：1996-29-8
- Empirical Formula: C6H3BrClF
- Molecular Weight: 209.44
- MDL number: MFCD00079708
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 1-Bromo-4-chloro-2-fluorobenzene?
Chemical properties
CLEAR COLORLESS TO PALE YELLOW LIQUID
The Uses of 1-Bromo-4-chloro-2-fluorobenzene
1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.
The Uses of 1-Bromo-4-chloro-2-fluorobenzene
A 2,4-dihalofluorobenzene derivative with antibacterial and antifungal activities.
General Description
1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines. The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.
Properties of 1-Bromo-4-chloro-2-fluorobenzene
| Boiling point: | 91-92 °C/20 mmHg (lit.) |
| Density | 1.678 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 198 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear colorless to pale yellow |
| Specific Gravity | 1.678 |
| Water Solubility | INSOLUBLE |
| BRN | 2081083 |
| CAS DataBase Reference | 1996-29-8(CAS DataBase Reference) |
Safety information for 1-Bromo-4-chloro-2-fluorobenzene
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 1-Bromo-4-chloro-2-fluorobenzene
| InChIKey | FPNVMCMDWZNTEU-UHFFFAOYSA-N |
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