1-Bromo-4-chloro-2-fluorobenzene

CAS NO.：1996-29-8
Empirical Formula: C6H3BrClF
Molecular Weight: 209.44
MDL number: MFCD00079708
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 1-Bromo-4-chloro-2-fluorobenzene?

Chemical properties

CLEAR COLORLESS TO PALE YELLOW LIQUID

The Uses of 1-Bromo-4-chloro-2-fluorobenzene

A 2,4-dihalofluorobenzene derivative with antibacterial and antifungal activities.

The Uses of 1-Bromo-4-chloro-2-fluorobenzene

1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.

General Description

1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines. The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.

Properties of 1-Bromo-4-chloro-2-fluorobenzene

Boiling point:	91-92 °C/20 mmHg (lit.)
Density	1.678 g/mL at 25 °C (lit.)
refractive index	n20/D 1.556(lit.)
Flash point:	198 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid
color	Clear colorless to pale yellow
Specific Gravity	1.678
Water Solubility	INSOLUBLE
BRN	2081083
CAS DataBase Reference	1996-29-8(CAS DataBase Reference)

Safety information for 1-Bromo-4-chloro-2-fluorobenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…