1-Acetylimidazole
- CAS NO.:2466-76-4
- Empirical Formula: C5H6N2O
- Molecular Weight: 110.11
- MDL number: MFCD00005287
- EINECS: 219-577-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-25 23:13:37
What is 1-Acetylimidazole?
Chemical properties
white to beige or light tan adhering crystals or
The Uses of 1-Acetylimidazole
It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives.
The Uses of 1-Acetylimidazole
Acetylating agent for capping unreacted amino groups in peptide synthesis.
The Uses of 1-Acetylimidazole
Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.
Definition
ChEBI: N-acetylimidazole is a N-acylimidazole.
General Description
Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported.
Purification Methods
It is recrystallised from isopropenyl acetate and dried in a vacuum over P2O5. [Riordan & Valee Methods Enzymol 25 500 1972, Beilstein 23/4 V 218.]
Properties of 1-Acetylimidazole
Melting point: | 99-105 °C (lit.) |
Boiling point: | 206.4°C (rough estimate) |
Density | 1.2111 (rough estimate) |
refractive index | 1.4800 (estimate) |
storage temp. | 2-8°C |
solubility | water: soluble50mg/mL, clear, colorless |
pka | pKa 3.6(H2O,t = 25,I=0.2) (Uncertain) |
form | Adhering Crystals or Crystalline Powder |
color | White to beige or light tan |
Water Solubility | Hydrolyzes in water. Solubility in methanol (almost transparency). |
Sensitive | Moisture Sensitive |
BRN | 108425 |
Stability: | Moisture Sensitive |
CAS DataBase Reference | 2466-76-4(CAS DataBase Reference) |
NIST Chemistry Reference | 1H-Imidazole, 1-acetyl-(2466-76-4) |
EPA Substance Registry System | 1H-Imidazole, 1-acetyl- (2466-76-4) |
Safety information for 1-Acetylimidazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Acetylimidazole
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