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HomeProduct name list1-Acetylimidazole

1-Acetylimidazole

  • CAS NO.:2466-76-4
  • Empirical Formula: C5H6N2O
  • Molecular Weight: 110.11
  • MDL number: MFCD00005287
  • EINECS: 219-577-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 23:13:37
1-Acetylimidazole Structural

What is 1-Acetylimidazole?

Chemical properties

white to beige or light tan adhering crystals or

The Uses of 1-Acetylimidazole

It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives.

The Uses of 1-Acetylimidazole

Acetylating agent for capping unreacted amino groups in peptide synthesis.

The Uses of 1-Acetylimidazole

Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.

Definition

ChEBI: N-acetylimidazole is a N-acylimidazole.

General Description

Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported.

Purification Methods

It is recrystallised from isopropenyl acetate and dried in a vacuum over P2O5. [Riordan & Valee Methods Enzymol 25 500 1972, Beilstein 23/4 V 218.]

Properties of 1-Acetylimidazole

Melting point: 99-105 °C (lit.)
Boiling point: 206.4°C (rough estimate)
Density  1.2111 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  2-8°C
solubility  water: soluble50mg/mL, clear, colorless
pka pKa 3.6(H2O,t = 25,I=0.2) (Uncertain)
form  Adhering Crystals or Crystalline Powder
color  White to beige or light tan
Water Solubility  Hydrolyzes in water. Solubility in methanol (almost transparency).
Sensitive  Moisture Sensitive
BRN  108425
Stability: Moisture Sensitive
CAS DataBase Reference 2466-76-4(CAS DataBase Reference)
NIST Chemistry Reference 1H-Imidazole, 1-acetyl-(2466-76-4)
EPA Substance Registry System 1H-Imidazole, 1-acetyl- (2466-76-4)

Safety information for 1-Acetylimidazole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1-Acetylimidazole

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