1-(3-Chlorophenyl)piperazine hydrochloride
Synonym(s):m-CPP;1-(3-Chlorophenyl)piperazine ammonium salt
- CAS NO.：65369-76-8
- Empirical Formula: C10H14Cl2N2
- Molecular Weight: 233.14
- MDL number: MFCD00039032
- EINECS: 265-718-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 1-(3-Chlorophenyl)piperazine hydrochloride?
Chemical properties
Off-white solid
The Uses of 1-(3-Chlorophenyl)piperazine hydrochloride
Chlorophenyl Piperazine Hydrochloride Salt is a useful intermediate for organic synthesis and other chemical properties. Trazodone impurity.
General Description
1-(3-Chlorophenyl)-piperazine, also known as meta-chlorophenylpiperazine or mCPP, is a designer drug analog of aryl-substituted piperazines. A stimulant, serotonin antagonist and reuptake inhibitor (SARU), mCPP can also be detected as a primary urinary metabolite of the antidepressant drug trazadone. This certified solution standard is suitable for use in piperazine testing methods by LC/MS or GC/MS for clinical toxicology, forensic analysis, or urine drug testing applications.
Biological Activity
5-HT 2C/2B receptor agonist/partial agonist; displays some activity at 5-HT 2A and 5-HT 1 receptors. pEC 50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT 2C , 2B and 2A , bovine 5-HT 1A and rat 5-HT 1B receptors respectively. Suppresses locomotor activity in rats in vivo .
Properties of 1-(3-Chlorophenyl)piperazine hydrochloride
| Melting point: | 210-214 °C (dec.)(lit.) |
| Density | 1,193g/cm |
| refractive index | 1,598-1,600 |
| Flash point: | 9℃ |
| storage temp. | Store at RT |
| solubility | methanol: soluble |
| form | Solid |
| color | Pale brown |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 65369-76-8(CAS DataBase Reference) |
Safety information for 1-(3-Chlorophenyl)piperazine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(3-Chlorophenyl)piperazine hydrochloride
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65369-76-8
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