1-(3-Chlorophenyl)piperazine hydrochloride

Synonym(s):m-CPP;1-(3-Chlorophenyl)piperazine ammonium salt

CAS NO.：65369-76-8
Empirical Formula: C10H14Cl2N2
Molecular Weight: 233.14
MDL number: MFCD00039032
EINECS: 265-718-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

1-(3-Chlorophenyl)piperazine hydrochloride Structural

What is 1-(3-Chlorophenyl)piperazine hydrochloride?

Chemical properties

Off-white solid

The Uses of 1-(3-Chlorophenyl)piperazine hydrochloride

Chlorophenyl Piperazine Hydrochloride Salt is a useful intermediate for organic synthesis and other chemical properties. Trazodone impurity.

General Description

1-(3-Chlorophenyl)-piperazine, also known as meta-chlorophenylpiperazine or mCPP, is a designer drug analog of aryl-substituted piperazines. A stimulant, serotonin antagonist and reuptake inhibitor (SARU), mCPP can also be detected as a primary urinary metabolite of the antidepressant drug trazadone. This certified solution standard is suitable for use in piperazine testing methods by LC/MS or GC/MS for clinical toxicology, forensic analysis, or urine drug testing applications.

Biological Activity

5-HT 2C/2B receptor agonist/partial agonist; displays some activity at 5-HT 2A and 5-HT 1 receptors. pEC 50 values are 7.09, 7.2, 6.65, 5.9 and 6.5 for human recombinant 5-HT 2C , 2B and 2A , bovine 5-HT 1A and rat 5-HT 1B receptors respectively. Suppresses locomotor activity in rats in vivo .

Properties of 1-(3-Chlorophenyl)piperazine hydrochloride

Melting point:	210-214 °C (dec.)(lit.)
Density	1,193g/cm
refractive index	1,598-1,600
Flash point:	9℃
storage temp.	Store at RT
solubility	methanol: soluble
form	Solid
color	Pale brown
Stability:	Hygroscopic
CAS DataBase Reference	65369-76-8(CAS DataBase Reference)

Safety information for 1-(3-Chlorophenyl)piperazine hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.