1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate
- CAS NO.：6903-79-3
- Empirical Formula: C4H12N3O4P
- Molecular Weight: 197.13
- MDL number: MFCD00868297
- EINECS: 230-011-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate?
Originator
Aplodan,Simes,Italy,1968
Definition
ChEBI: Creatinolfosfate is a phosphoethanolamine.
Manufacturing Process
In a reactor put 80 kg of polyphosphoric acid having the following
composition: H5P3O10 - 60%; (HPO3)6 - 10%; H4P2O7 - 15%; (HPO3)x - 10%;
total content in P2O5 about 83%; this is heated to about 160°C.
Then 360 kg of creatinol phosphate are added to the polyphosphoric acid;
continue to heat for about two hours under vacuum until the reaction water is
eliminated.
The molten mass is then poured into ethanol at 95°C, the solution cooled
down to 10°C and the precipitated product separated by centrifugation. The
resulting product is dissolved in the minimum quantity of warm water and the
solution poured into ethanol.
Thus 297 kg of the phosphoric ester of the creatinol are obtained having these
characteristics: MP 240°C to 243°C.
Therapeutic Function
Cardiotonic
Properties of 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate
| Melting point: | 244 °C(dec.) |
| Boiling point: | 244°C(lit.) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| form | powder to crystal |
| pka | 1.84±0.10(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 6903-79-3(CAS DataBase Reference) |
Safety information for 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate
| InChIKey | FOIPWTMKYXWFGC-UHFFFAOYSA-N |
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