(+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Synonym(s):trans-Cyclohexane-1,2-dicarboxylic acid anhydride;trans-Hexahydro-1,3-isobenzofurandione;trans-Hexahydrophthalic anhydride
- CAS NO.:14166-21-3
- Empirical Formula: C8H10O3
- Molecular Weight: 154.16
- MDL number: MFCD00064345
- EINECS: 238-009-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE?
The Uses of (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Trans-1,2-cyclohexanedicarboxylic anhydride can be used as a reagent to prepare hepatitis C virus (HCV) and granzyme B (indoline derivatives) inhibitors. It has also been employed in studies relating to the development of protein kinase C inhibitors.
Purification Methods
Crystallise the anhydride from *C6H6/Et2O. It has been obtained by heating the cis-acid or anhydride with HCl at 180o for 3hours. It can be obtained from the acid by heating in Ac2O. It sublimes at 125-135o/0.02mm. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Fichter & Simon Helv Chim Acta 17 1218 1934, Beilstein 9 IV 2802.]
Properties of (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Melting point: | 145-147 °C(lit.) |
Boiling point: | 283.4±0.0 °C(Predicted) |
Density | 1.235±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | Acetone (Sparingly), Chloroform (Slightly), DMSO (Slightly) |
form | Solid |
color | White to Pale Beige |
Stability: | Moisture Sensitive |
CAS DataBase Reference | 14166-21-3 |
Safety information for (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for (+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin B Tubulysin E Tubulysin H Tubulysin G (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 1-(4-Fluorophenyl)piperidin-2-one 4-(Azidomethyl)-3-chloropyridine 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine 5-Aminophthalazine (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine 6-bromopyridazin-3-amineRelated products of tetrahydrofuran
Lithium bis(trimethylsilyl)amide
Hexahydrophthalic anhydride
BUTYLSUCCINIC ANHYDRIDE
(+)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
Methyl cyclohexanecarboxylate
(+/-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
(R)-BETA-METHYL-GAMMA-BUTYROLACTONE
(-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE,(-)-TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE 98+%
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