(-)-PERILLYL ALCOHOL

Synonym(s):(S)-p-Mentha-1,8-dien-7-ol;(S)-4-Isopropenyl-1-cyclohexenylmethanol;p-Mentha-1,8-diene-7-ol

CAS NO.：18457-55-1
Empirical Formula: C10H16O
Molecular Weight: 152.23
MDL number: MFCD00062995
EINECS: 629-611-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 08:26:49

What is (-)-PERILLYL ALCOHOL?

Description

(–)-Perillyl alcohol is a monoterpene alcohol that has been found in lavender essential oil and has diverse biological activities. It reduces production of hydroperoxidienes and thiobarbituric acid reactive substances (TBARS) in vitro in a concentration-dependent manner. (–)-Perillyl alcohol inhibits PANC-1 pancreatic carcinoma cell and H-Ras-transformed fibroblast growth when used at a concentration of 1 mM. It also inhibits the growth of P. aeruginosa, E. coli, S. aureus, and C. albicans (MICs = 480-2,900 ppm).

The Uses of (-)-PERILLYL ALCOHOL

(-)-Perillyl Alcohol is a monoterpene that induces apoptosis in colon tumor cells. Also, it is used in preparation of terpene-vanilloid conjugates as anti-inflammatory agents.

What are the applications of Application

(?)-Perillyl Alcohol is A monoterpene that induces apoptosis in colon tumor cells

Definition

ChEBI: (S)-(-)-perillyl alcohol is a perillyl alcohol in which the chiral centre has S configuration. It is an enantiomer of a (R)-(+)-perillyl alcohol.

General Description

(S)-(-)-Perillyl alcohol is a monoterpenoid compound found in the essential oils of cherries, lavender and spearmint. It shows potent anticancer activity.

Properties of (-)-PERILLYL ALCOHOL

Boiling point:	119-121 °C11 mm Hg(lit.)
alpha	-101o (NEAT)
Density	0.96 g/mL at 25 °C(lit.)
refractive index	n20/D 1.501
Flash point:	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Sparingly)
form	neat
pka	14.85±0.10(Predicted)
form	Liquid
Specific Gravity	0.960
color	Colourless
optical activity	[α]22/D 88°, c = 1 in methanol
BRN	2501605
CAS DataBase Reference	18457-55-1(CAS DataBase Reference)

Safety information for (-)-PERILLYL ALCOHOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.