(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
- CAS NO.:72795-01-8
- Empirical Formula: C17H28ClNO2
- Molecular Weight: 313.87
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride?
Description
ICI 118551 is a potent, selective antagonist of the β2-
The Uses of (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
The (R,R)-enantiomer
The Uses of (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.
The Uses of (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
ICI 118,551 hydrochloride has been used:
- to block β-adrenergic signaling in various experiments
- to counteract degradation by endogenous T-lymphocyte monoamine oxidases
- to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts
What are the applications of Application
ICI 118,551 hydrochloride is a selective β2 adrenergic antagonist.
Biochem/physiol Actions
ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.
storage
Store at RT
Properties of (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
storage temp. | desiccated |
solubility | DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic) |
form | powder |
color | white |
Safety information for (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
Computed Descriptors for (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
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