(-)-CAMPHOR

Synonym(s):(−)-Camphor;(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

CAS NO.：464-48-2
Empirical Formula: C10H16O
Molecular Weight: 152.23
MDL number: MFCD00064148
EINECS: 207-354-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is (-)-CAMPHOR?

Chemical properties

white crystals

The Uses of (-)-CAMPHOR

(1S)-(-)-Camphor is used as chiral intermediate and chiral auxiliary precursor. It is used in the synthesis of high-potency sweeteners. It acts as catalytic agent and petrochemical additive.

Definition

ChEBI: The S-enantiomer of camphor.

General Description

Colorless or white crystals. Fragrant and penetrating odor. Slightly bitter and cooling taste. Odor index at 68°F: 40. Flash point 149°F. Burns with a bright, smoky flame. Sublimes appreciably at room temperature and pressure; 14% sublimes within 60 minutes at 176°F and 12 mm Hg.

Air & Water Reactions

Flammable. Slightly water soluble.

Reactivity Profile

(-)-CAMPHOR may be sensitive to heat and direct sunlight. Incompatible with strong oxidizing agents, strong reducing agents and chlorinated solvents. Also incompatible with potassium permanganate. Salts of any kind should not be added to (-)-CAMPHOR in water. Reacts violently with chromic anhydride .

Fire Hazard

(-)-CAMPHOR is flammable.

Purification Methods

Crystallise it from EtOH, 50% EtOH/water, MeOH, or pet ether or from glacial acetic acid by addition of water. It can be sublimed (50o/14mm) and also fractionally crystallised from its own melt. It is steam volatile. It should be stored in tight containers as it is appreciably volatile at room temperature. The solubility is 0.1% (H2O), 100% (EtOH), 173% (Et2O) and 300%

Properties of (-)-CAMPHOR

Melting point:	177-179 °C(lit.)
Boiling point:	204 °C(lit.)
alpha	-44.8° (20/D)(EtOH)
Density	0.990
vapor density	5.24 (vs air)
vapor pressure	4 mm Hg ( 70 °C)
refractive index	-44 ° (C=20, EtOH)
Flash point:	148 °F
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form	Adhering Crystals or Crystalline Powder
color	White to yellow
Specific Gravity	0.9853 (18℃)
Odor	at 10.00 % in dipropylene glycol. camphor
optical activity	[α]20/D 43°, c = 10 in ethanol
explosive limit	0.6-4.5%(V)
Water Solubility	Soluble in water. (0.34 g/L) at 20°C
Merck	14,1732
BRN	4291747
Stability:	Stable. Incompatible with strong reducing agents, strong oxidizing agents, chlorinated solvents. Protect from direct sunlight.
CAS DataBase Reference	464-48-2(CAS DataBase Reference)
EPA Substance Registry System	l-Camphor (464-48-2)

Safety information for (-)-CAMPHOR

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H228:Flammable solids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.