(-)-Arctigenin
Synonym(s):(−)-Arctigenin;(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone;2(3H)-Furanone
- CAS NO.：7770-78-7
- Empirical Formula: C21H24O6
- Molecular Weight: 372.41
- MDL number: MFCD00870597
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 13:47:35
What is (-)-Arctigenin?
The Uses of (-)-Arctigenin
Arctigenin is a plant ligan associated with anticancer and antioxidant properties.
What are the applications of Application
Arctigenin is a dibenzyl butyrolactone lignan with antiinflammatory and antioxidant properties
Definition
ChEBI: (-)-Arctigenin is a lignan.
Biological Activity
Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I κ B α phosphorylation and p65 nuclear translocation (IC 50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (IC 50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.
storage
-20°C (desiccate)
Properties of (-)-Arctigenin
| Melting point: | 98.0 to 102.0 °C |
| Boiling point: | 567.0±45.0 °C(Predicted) |
| Density | 1.227±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: 34 mg/mL with heating and sonicating, soluble |
| form | solid |
| pka | 10.03±0.20(Predicted) |
| color | White to Light yellow |
| λmax | 280nm(EtOH)(lit.) |
| CAS DataBase Reference | 7770-78-7(CAS DataBase Reference) |
Safety information for (-)-Arctigenin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (-)-Arctigenin
| InChIKey | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
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