(-)-Arctigenin

Synonym(s):(−)-Arctigenin;(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone;2(3H)-Furanone

CAS NO.：7770-78-7
Empirical Formula: C21H24O6
Molecular Weight: 372.41
MDL number: MFCD00870597
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-07 13:47:35

What is (-)-Arctigenin?

The Uses of (-)-Arctigenin

Arctigenin is a plant ligan associated with anticancer and antioxidant properties.

What are the applications of Application

Arctigenin is a dibenzyl butyrolactone lignan with antiinflammatory and antioxidant properties

Definition

ChEBI: (-)-Arctigenin is a lignan.

Biological Activity

Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I κ B α phosphorylation and p65 nuclear translocation (IC 50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (IC 50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

storage

-20°C (desiccate)

Properties of (-)-Arctigenin

Melting point:	98.0 to 102.0 °C
Boiling point:	567.0±45.0 °C(Predicted)
Density	1.227±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 34 mg/mL with heating and sonicating, soluble
form	solid
pka	10.03±0.20(Predicted)
color	White to Light yellow
λmax	280nm(EtOH)(lit.)
CAS DataBase Reference	7770-78-7(CAS DataBase Reference)

Safety information for (-)-Arctigenin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.