(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
- CAS NO.：121083-05-4
- Empirical Formula: C22H21F2NO4S
- Molecular Weight: 433.47
- MDL number: MFCD00880316
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
![(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Structural](https://img.chemicalbook.in/CAS/GIF/121083-05-4.gif)
What is (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID?
The Uses of (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
L-670,596 is a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
Definition
ChEBI: 2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid is a member of carbazoles.
Biological Activity
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo .
Properties of (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
| Boiling point: | 693.4±55.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 100 mM in 1.1eq. NaOH |
| form | Powder |
| pka | 4.56±0.10(Predicted) |
Safety information for (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
Computed Descriptors for (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
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