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HomeProduct name list7-Fluoroindole

7-Fluoroindole

  • CAS NO.:387-44-0
  • Empirical Formula: C8H6FN
  • Molecular Weight: 135.14
  • MDL number: MFCD01074502
  • EINECS: 640-248-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-06-25 20:17:06
7-Fluoroindole Structural

What is 7-Fluoroindole?

Chemical properties

Brown solid

The Uses of 7-Fluoroindole

7-Fluoroindole is a reagent used in chemical synthesis. It has been used to synthesize antiviral compounds against Pseudomonas aeruginosa and Staphylococcus aureus along with creation of immunomodulators. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Antimicrobial activity

7-fluoroindole (7FI) was identified as a compound that inhibits biofilm formation and blood hemolysis without inhibiting the growth of planktonic P. aeruginosa cells. Moreover, 7FI markedly reduced the production of quorum-sensing (QS)-regulated virulence factors 2-heptyl-3-hydroxy-4(1H)-quinolone, pyocyanin, rhamnolipid, two siderophores, pyoverdine and pyochelin. 7FI clearly suppressed swarming motility, protease activity and the production of a polymeric matrix in P. aeruginosa. However, unlike natural indole compounds, synthetic 7FI did not increase antibiotic resistance. Therefore, 7FI is a potential candidate for use in an antivirulence approach against persistent P. aeruginosa infection.

Properties of 7-Fluoroindole

Melting point: 61 °C
Boiling point: 258.0±13.0 °C(Predicted)
Density  1.273±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in methanol. (almost transparency)
form  powder to crystal
pka 15.55±0.30(Predicted)
color  White to Light yellow to Light orange
BRN  114740
CAS DataBase Reference 387-44-0(CAS DataBase Reference)

Safety information for 7-Fluoroindole

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for 7-Fluoroindole

InChIKey XONKJZDHGCMRRF-UHFFFAOYSA-N

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