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9039-53-6

Product Name: Urokinase
Formula: C21H25BrN2O3
Synonyms: u-Plasminogen activator
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CHEMICAL AND PHYSICAL PROPERTIES

Melting Point 76 °C at pH 4.5
Hydrophobicity -0.466
Isoelectric Point 8.66

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Health Hazard
GHS08
GHS Hazard Statements H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P284:Wear respiratory protection.
P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight 302.35 g/mol
XLogP3 2.9
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 4
Exact Mass 302.08374688 g/mol
Monoisotopic Mass 302.08374688 g/mol
Topological Polar Surface Area 108 Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 382
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978.