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85441-61-8

85441-61-8 structural image
Product Name: Quinapril
Formula: C25H30N2O5
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 120-130 °C
Solubility 8.50e-03 g/L
LogP 0.86
Dissociation Constants 2.8
Collision Cross Section 204.4 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated]

COMPUTED DESCRIPTORS

Molecular Weight 438.5 g/mol
XLogP3 1.2
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 10
Exact Mass 438.21547206 g/mol
Monoisotopic Mass 438.21547206 g/mol
Topological Polar Surface Area 95.9 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 648
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.

RELATED SUPPLIERS

Ralington Pharma

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product:85441-61-8 Quinapril 98%
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