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6591-63-5

6591-63-5 structural image
Product Name: Quinidine sulfate dihydrate
Formula: C20H26N2O6S
Synonyms: Quinidine sulfate salt dihydrate
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CHEMICAL AND PHYSICAL PROPERTIES

Color/Form Occurs as fine, needle-like, white crystals which frequently cohere in masses or as a fine, white powder.
Taste Very bitter taste
Solubility WHITE; VERY BITTER; ODORLESS; FINE CRYSTALS; FREQUENTLY COHERING IN MASSES; PH (1% AQUEOUS SOLN): 6.0-6.8 PKA: 4.2, 8.8; SPECIFIC OPTICAL ROTATION: +212 @ 25 °C/D (95% ALCOHOL); ABOUT + 260 @ 25 °C/D (DILUTE HYDROCHLORIC ACID); DOES NOT LOSE ALL OF ITS WATER BELOW 120 °C 1 G DISSOLVES IN ABOUT 90 ML WATER, 15 ML BOILING WATER, 10 ML ALCOHOL, 3 ML METHANOL, 12 ML CHLOROFORM; INSOL IN ETHER, BENZENE; /DIHYDRATE/
Stability/Shelf Life PROTECT FROM LIGHT; DARKENS ON EXPOSURE TO LIGHT /DIHYDRATE/
Optical Rotation Specific optical rotation: + 212 deg at 25 °C/D (alcohol); prisms; needles from water. /d-quinidine sulfate/
Decomposition When heated to decomposition it emits very toxic fumes of /nitrogen oxides and sulfur oxides/.
Refractive Index INDEX OF REFRACTION ALPHA 1.565; BETA 1.607; GAMMA 1.670. OPTIC SIGN +, EXTINCTION PARALLEL, ELONGATION +
Other Experimental Properties ODORLESS; VERY BITTER TASTE; SOLN ARE NEUTRAL OR ALKALINE TO LITMUS

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight 782.9 g/mol
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 14
Rotatable Bond Count 8
Exact Mass 782.35606511 g/mol
Monoisotopic Mass 782.35606511 g/mol
Topological Polar Surface Area 176 Ų
Heavy Atom Count 55
Formal Charge 0
Complexity 538
Isotope Atom Count 0
Defined Atom Stereocenter Count 8
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 5
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Quinidine Sulfate is the sulfate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine sulfate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine sulfate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the rate of phase 0 depolarization and prolonging the refractory period. Quinidine sulfate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart.

RELATED SUPPLIERS

Chempifine Chemicals

1Y
product:50-54-4 / 11034-22-3 Quinidine sulfate 98%

Inga Pharmaceuticals

1Y
product:50-54-4 / 11034-22-3 99%

Prism Industries Ltd

1Y
product:6591-63-5 99%
All suppliers(4)