CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
---|---|
Color/Form | Oil |
Melting Point | 225 °C (hydrochloride salt) |
Solubility | Sparingly soluble (hydrochloride salt) |
LogP | 4.9 |
Dissociation Constants | 9.54 |
Other Experimental Properties | Crystals from alcohol/water. Two distinct crystalline forms have been identified /Azelastine monohydrate/ |
COMPUTED DESCRIPTORS
Molecular Weight | 381.9 g/mol |
---|---|
XLogP3 | 4.4 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 3 |
Exact Mass | 381.1607901 g/mol |
Monoisotopic Mass | 381.1607901 g/mol |
Topological Polar Surface Area | 35.9 Ų |
Heavy Atom Count | 27 |
Formal Charge | 0 |
Complexity | 558 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Azelastine is a phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. It has a role as a H1-receptor antagonist, an anti-allergic agent, an anti-asthmatic drug, a bronchodilator agent, a platelet aggregation inhibitor and an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor. It is a member of phthalazines, a tertiary amino compound and a member of monochlorobenzenes.