CHEMICAL AND PHYSICAL PROPERTIES
| Solubility | 100 mg/mL |
|---|---|
| LogP | -3 |
| Optical Rotation | Specific optical rotation: +164 deg at 26 °C/D (3 in water) |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating fumes. |
COMPUTED DESCRIPTORS
| Molecular Weight | 475.6 g/mol |
|---|---|
| XLogP3 | -4.2 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 8 |
| Exact Mass | 475.30059866 g/mol |
| Monoisotopic Mass | 475.30059866 g/mol |
| Topological Polar Surface Area | 200 Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 673 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 11 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect of netilmiicin is not fully understood.