CHEMICAL AND PHYSICAL PROPERTIES
| Melting Point | 200-220 °C |
|---|---|
| Solubility | 564000 mg/L |
| LogP | -2.4 |
| Stability/Shelf Life | DRY POWDER IS STABLE INDEFINITELY. /COLESTIN SULFATE/ |
| Decomposition | When heated to decomposition it emits toxic fumes of nitroxides. |
| Chemical Classes | Other Uses -> Pharmaceuticals |
COMPUTED DESCRIPTORS
| Molecular Weight | 1155.4 g/mol |
|---|---|
| XLogP3 | -3.3 |
| Hydrogen Bond Donor Count | 18 |
| Hydrogen Bond Acceptor Count | 18 |
| Rotatable Bond Count | 28 |
| Exact Mass | 1154.74992724 g/mol |
| Monoisotopic Mass | 1154.74992724 g/mol |
| Topological Polar Surface Area | 491 Ų |
| Heavy Atom Count | 81 |
| Formal Charge | 0 |
| Complexity | 2050 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 11 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.