CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Oily liquid |
| Odor | Amine odor |
| Boiling Point | 200-205 °C at 8.00E-01 mm Hg |
| Melting Point | 177-178 |
| Solubility | 2.55 mg/L (at 24 °C) |
| LogP | 5.41 |
| LogS | -5.01 |
| Stability/Shelf Life | Chlorpromazine and its hydrochloride salt darken on prolonged exposure to light. Commercially available preparations of chlorpromazine and its hydrochloride salt should be protected from light. |
| Decomposition | When heated to decomposition it emits very toxic fumes of /hydrogen chloride/, nitroxides, and sulfoxides. |
| pH | Alkaline reaction |
| Caco2 Permeability | -4.7 |
| Dissociation Constants | 9.24 |
| Collision Cross Section | 170.6 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2525 2443 2480 2474 2481 2474 2452 2490 2479 2526 2499 2540 2525 2486 2487 2480.1 2484 2490.2 2504 2480 2486 2440 2452 2474 2480 2481 2500 2480 2490 2486 2514.4 2440 2515 2538 2490 2490 2449.5 |
| Other Experimental Properties | Max absorption: 250 nm (log e = 4.5); 300 nm (log e = 3.5) /Chlorpromazine hydrochloride/ |
| Chemical Classes | Other Uses -> Pharmaceuticals |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 318.9 g/mol |
|---|---|
| XLogP3 | 5.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 318.0957475 g/mol |
| Monoisotopic Mass | 318.0957475 g/mol |
| Topological Polar Surface Area | 31.8 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 339 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Chlorpromazine is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. It has a role as a phenothiazine antipsychotic drug, an antiemetic, a dopaminergic antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an anticoronaviral agent. It is a member of phenothiazines, an organochlorine compound and a tertiary amine.