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58-38-8

58-38-8 structural image
Product Name: Prochlorperazine
Formula: C20H24ClN3S
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form Viscous liquid
Melting Point 228 °C
Solubility 15 mg/L (at 24 °C)
LogP 4.88
LogS -4.4
Stability/Shelf Life SENSITIVE TO LIGHT.
Decomposition When heated to decomposition it emits very toxic fumes of sulfoxides, nitroxides, and /hydrogen chloride/.
Dissociation Constants 8.1
Collision Cross Section 183.7 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Kovats Retention Index 2937 2965 2970 2954 2970 2945.2 2980.7 2943 2997 2983 2921 2985 2954 2947.2
Other Experimental Properties Minute crystals; Solubility in water: less than 0.1% at 20 °C; slightly soluble in methanol, ethanol; practically insoluble in ether, benzene, chloroform; MP: 228 °C /Prochlorperazine dimaleate/

COMPUTED DESCRIPTORS

Molecular Weight 373.9 g/mol
XLogP3 4.9
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 4
Exact Mass 373.1379466 g/mol
Monoisotopic Mass 373.1379466 g/mol
Topological Polar Surface Area 35 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 429
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Prochlorperazine is a member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. It has a role as an antiemetic, a dopaminergic antagonist, an alpha-adrenergic antagonist, a cholinergic antagonist, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and a dopamine receptor D2 antagonist. It is an organochlorine compound, a N-alkylpiperazine, a N-methylpiperazine and a member of phenothiazines. It derives from a hydride of a 10H-phenothiazine.

RELATED SUPPLIERS

Ralington Pharma

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product:58-38-8 Prochlorperazine 98%
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