3483-12-3
Product Name:
DL-Dithiothreitol
Formula:
C4H10O2S2
Synonyms:
DTT;1,4-Dithiothreitol;Cleland’s reagent;Dithiothreitol, DTT;(±)-threo-1,4-Dimercapto-2,3-butanediol solution
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Slightly hygroscopic solid; [Merck Index] White powder; [Sigma-Aldrich MSDS] |
|---|---|
| Color/Form | Needles from ether |
| Odor | Characteristic |
| Boiling Point | BP: 115-116 °C at 1 mm Hg |
| Melting Point | 42-43 °C |
| Solubility | Freely soluble in water |
| Stability/Shelf Life | Chemical stability: May decompose on exposure to moist air or water. Stable under recommended storage conditions. |
| Decomposition | Hazardous decomposition products formed under fire conditions: Carbon oxides, sulfur oxides. |
| Other Experimental Properties | Slightly hygroscopic |
| Chemical Classes | Other Uses -> Biochemical Research |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 154.3 g/mol |
|---|---|
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 154.01222190 g/mol |
| Monoisotopic Mass | 154.01222190 g/mol |
| Topological Polar Surface Area | 42.5 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 52 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
DL-Dithiothreitol (DTT) is extensively applied in chemical peptide synthesis and biochemical preparations of thiol proteins. It is also used in protein chemistry studies, such as protein folding and enzyme activity. It also acts as an enzyme stabilizer to stop DNA modification.