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111406-87-2

111406-87-2 structural image
Product Name: Zileuton
Formula: C11H12N2O2S
Synonyms: (±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea;Zileuton
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 144.2-145.2 °C
Solubility Practically insoluble (0.5 mg/ml)
LogP 0.9

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07

Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.

COMPUTED DESCRIPTORS

Molecular Weight 236.29 g/mol
XLogP3 1.6
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 2
Exact Mass 236.06194880 g/mol
Monoisotopic Mass 236.06194880 g/mol
Topological Polar Surface Area 94.8 Ų
Heavy Atom Count 16
Formal Charge 0
Complexity 275
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Zileuton is a member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. It has a role as an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, a non-steroidal anti-inflammatory drug, an anti-asthmatic drug, a leukotriene antagonist and a ferroptosis inhibitor. It is a member of ureas and a member of 1-benzothiophenes. It derives from a hydride of a 1-benzothiophene.

RELATED SUPPLIERS

Sekhment pharmaventures

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product:Zileuton 99%

Solara Active Pharma Sciences Ltd

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product:111406-87-2 98%

Biophore India Pharmaceuticals Pvt Ltd

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product:Zileuton 111406-87-2 98%

Mylan Laboratories Ltd

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product:111406-87-2 Zileuton 98%

Apicore Pharmaceuticals Pvt Ltd

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product:111406-87-2 98%

Aspen Biopharma Labs Pvt Ltd

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product:Zileuton 111406-87-2 98%

AKASH PHARMA EXPORTS

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product:Zileuton 99%
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