factory Levamisole?cas?14769-73-4

Price	USD50.00
Packge	1KG

Product Details

Product Name Levamisole
CAS No.14769-73-4
EINECS No.200-002-5
MFC11H12N2S
MW204.29
AppearanceSolidOff-White to Pale Yellow
storage temp. Sealed in dry,2-8°C
Melting point 60-61.5°
Boiling point 344.4±45.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)

Product Name:	Levamisole
Synonyms:	L-6-PHENYL-2,3,5,6-TETRAHYDROIMIDAZOL(2,1-B) THIAZOLE;IMMUNOPURE(R) PHOSPHATASE SUPPRESSOR;LEVAMISOLE;LEVAMISOLE BASE;(s)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;lepuron;levomysol;l-tetramisole
CAS:	14769-73-4
MF:	C11H12N2S
MW:	204.29
EINECS:	238-836-5
Product Categories:
Mol File:	14769-73-4.mol

Levamisole Chemical PropertiesMelting point 60-61.5°alpha D25 -85.1° (c = 10 in chloroform)Boiling point 344.4±45.0 °C(Predicted)density 1.32±0.1 g/cm3(Predicted)storage temp. 0-6°Cpka10.00±0.40(Predicted)CAS DataBase Reference14769-73-4(CAS DataBase Reference)EPA Substance Registry SystemLevamisole (14769-73-4)

Safety Information

MSDS Information

Levamisole Usage And SynthesisPharmacology and mechanism of actionLevamisole is the L-isomer of tetramisole and is more active than the racemic mixture. It was introduced in 1966 as a veterinary drug and a little later as a human anthelminthic drug against ascariasis. The drug has also shown to be effective against hookworms (Ancylostoma duodenale and Necator americanus), but results of reported studies are inconsistent ^[1]. The mechanism of action of levamisole in helminthiasis is through its stimulation of autonomic ganglia (nicotinic receptors) of the worms. On exposure to the drug, immature and adult worms show spastic contraction followed by tonic paralysis. This mechanism seems to be common to other anthelminthics such as pyrantel and bephenium hydroxynaphthoate ^[2]. In higher doses, levamisole acts as an immunostimulant. It restores depressed cell-mediated immune mechanisms in peripheral T-lymphocytes, but may have marginal effects in immunologically competent individuals ^[3]. The clinical implication of this effect in the treatment of helminthiasis is unknown. IndicationsMonoinfections with Ascaris lumbricoides. In polyinfections, mebendazole is the drug of choice. Side effectsDuring the treatment of nematode infections the drug produces minor side effects including nausea, vomiting, abdominal pain and headache^{[4, 5]}. During prolonged treatment as an immunomodulator in rheumatic arthritis and in cancer patients, serious side effects such as blood disorders (agranulocytosis, neutropenia and thrombocytopenia), kidney damage, influenza-like reactions, vasculitis, photosensitivity and allergy to the drug have been reported ^{[6, 7]}. Contraindications and precautionsThe drug should be avoided in patients allergic to the drug. Administration of levamisole may provoke a reaction similar to that seen after intake of alcohol together with disulfiram. During long-term treatment, patients with kidney damage or with blood disorders may experience exacerbation of their diseases. InteractionsLevamisole has been reported to displace the protein binding of rifampicin in vitro^[8]. The clinical significance of this is as yet unknown. PreparationsAvailable as levamisole hydrochloride: 118 mg is equivalent to 100 mg base.
• Ketrax® (Zeneca). Oral solution 40 mg base per 5 ml. Tablets 40 mg base.
• Solaskil® (Rhône-Poulenc Rorer). Tablets 30 mg base, 150 mg base.
• Ergamisol® (Lederle). Tablets 50 mg base.
• Levamisol® (Janssen). Tablets 50 mg base. References1. Miller MJ (1980). Use of levamisole in parasitic infections. Drugs, 19, 122–130.
2. van Wauwe J, Janssen PAJ (1991). On the biochemical mode of action of levamisole: an update. Int J Immunopharmacol, 13, 3–9.
3. Renoux G (1980). The general immunopharmacology of levamisole. Drugs, 19, 89–99.
4. Lionel ND, Mirando EH, Nanayakkara JC, Soysa PE (1969). Levamisole in the treatment of ascariasis in children. BMJ, 4, 340–341.
5. Farid Z, Bassily S, Miner WF, Hassan A, Laughli LW (1977). Comparative single-dose treatment of hookworm and roundworm infections with levamisole, pyrantel and bephenium. J Trop Med Hyg, 80, 107–108.
6. Chrisp P, McTavish D (1991). Levamisole/fluorouracil: A review of their pharmacology and adjuvant therapeutic use in colorectal cancer. Drugs & Aging, 14, 317–337.
7. Amery WK, Butterworth BS (1983) The dosage regimen of levamisole in cancer: is it related to efficacy and safety Int J Immunopharmacol, 5, 1–9.
8. Pérez-Gallardo L, Blanco ML, Soria H, Escanero JF (1992). Displacement of rifampicin bound to serum proteins by addition of levamisole. Biomed Pharmacother, 46, 173–174. OriginatorSolaskil,Specia,France,1971UsesBiological response modifier.UsesLevamisole is used for initial and secondary immunodeficient conditions, autoimmune diseases, chronic and reoccurring infections, large intestine adenocarcinoma, helmintosis, and rheumatoid arthritis. Synonyms of this drug are decaris, tetramizole, and others.
Levimasole is also a drug of choice for ascardiasis. Numerous investigations show that a single dose of levamisole heals from 90 to 100% of patients with ascardiasis, in particular those infected with A. duodenale. It is less effective against ancylostomiasis and strongyloidiasis. However, it is not effective against N. americanus. It seems likely that it has a gangliostimulating effect on parasite tissues in both the parasympathetic and sympathetic regions. Moreover, it is presumed that this drug has an immunomodulatory effect on the host organism. Synonyms of this drug are decaris, solacil, ergamisol, tramisol, immunol, and others.

Company Profile Introduction

Shijiazhuang Tongyang Import and Export Co., LTD , located in Shijiazhuang City,which is the capital of Hebei Province and hub sector among Beijing, Tianjin, and Hebei.We have the advantage of convenient transportation.Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.In recent five years, the company has implemented the strategy of "going out" vigorously.We has established our branches in Hubei China, Vietnam and Mexico, making our market and sales network more and more perfect.Our company will continue to adhere to the strategic positioning of fine chemical industry in the future and competition ideas of irreplaceable product differentiation,and strive to become to the leading of Chinese chemical industry.Shijiazhuang Tongyang Import and Export Co., LTD , located in Shijiazhuang City,which is the capital of Hebei Province and hub sector among Beijing, Tianjin, and Hebei.We have the advantage of convenient transportation.Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.In recent five years, the company has implemented the strategy of "going out" vigorously.We has established our branches in Hubei China, Vietnam and Mexico, making our market and sales network more and more perfect.Our company will continue to adhere to the strategic positioning of fine chemical industry in the future and competition ideas of irreplaceable product differentiation,and strive to become to the leading of Chinese chemical industry.

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2024-01-31