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HomeProduct name listZolenzepine

Zolenzepine

Zolenzepine Structural

What is Zolenzepine?

Originator

Zolenzepine,ZYF Pharm Chemical

Manufacturing Process

3.5 g of 4-chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3- b][1,5]benzodiazepin-10-one, 8.1 g of N-methylpiperazine and 50 ml of toluene are stirred at 80°C for 2 h. 60 ml of dilute sodium bicarbonate solution are added to the mixture, the layers are separated and the aqueous phase is extracted by shaking it with toluene several times more before concentrating it to dryness in vacuum. The residue is stirred with 100 ml of isopropanol and is filtered; the filtrate is concentrated in vacuum. The residue (4.0 g) is purified by stirring it with diethyl ether and by recrystallizing it from toluene, which yields 2.2 g of 1,3-dimethyl-4-[(4-methylpiperazin-1-yl)acetyl]-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one, melting point 186-188°C.

Therapeutic Function

Antiulcer

Safety information for Zolenzepine

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