Zolenzepine
- CAS NO.:78208-13-6
- Empirical Formula: C19H24N6O2
- Molecular Weight: 368.43
- MDL number: MFCD00868839
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is Zolenzepine?
Originator
Zolenzepine,ZYF Pharm Chemical
Manufacturing Process
3.5 g of 4-chloroacetyl-1,3-dimethyl-1,4,9,10-tetrahydropyrazolo[4,3- b][1,5]benzodiazepin-10-one, 8.1 g of N-methylpiperazine and 50 ml of toluene are stirred at 80°C for 2 h. 60 ml of dilute sodium bicarbonate solution are added to the mixture, the layers are separated and the aqueous phase is extracted by shaking it with toluene several times more before concentrating it to dryness in vacuum. The residue is stirred with 100 ml of isopropanol and is filtered; the filtrate is concentrated in vacuum. The residue (4.0 g) is purified by stirring it with diethyl ether and by recrystallizing it from toluene, which yields 2.2 g of 1,3-dimethyl-4-[(4-methylpiperazin-1-yl)acetyl]-1,4,9,10-tetrahydropyrazolo[4,3-b][1,5]benzodiazepin-10-one, melting point 186-188°C.
Therapeutic Function
Antiulcer
Safety information for Zolenzepine
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