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HomeProduct name listZilpaterol hydrochloride

Zilpaterol hydrochloride

Synonym(s):(6RS,7RS)-4,5,6, 7-Tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]imidazo[ 4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride

Zilpaterol hydrochloride Structural

What is Zilpaterol hydrochloride?

Description

Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues. It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle.

Definition

Zilpaterol hydrochloride, (±)-trans-4,5,6,7-tetrahydro-7-hydroxy-6-(isopropylamino) imidazo[4,5,1-jk]-[1]benzazepin-2(1H)-one hydrochloride; (zilpaterol HCl; CAS No. 119520- 06-8), is a β2-adrenoreceptor agonist repartitioning agent (FAO, 2013). It is used to increase rate of body weight gain, improve feed efficiency and increase carcass muscle ratio in cattle fed in confinement before slaughter . There are four enantiomers of zilpaterol HCl. The product in use is racemic trans-zilpaterol HCl, a mixture of the (6R,7R) and (6S,7S) enantiomers.

Materials Uses

Zilpaterol hydrochloride is marketed as a compound that will increase rate of BW gain, improve feed efficiency, and increase carcass leanness in cattle fed in confinement systems. Zilpaterol hydrochloride has also been shown to increase weight of gross primal and boneless closely trimmed primals, and boneless closely trimmed retail cuts as a percentage of carcass weight, when carcass weights were held constant (Plascencia et al., 1999). Additionally, slaughtering a lot of cattle on the same date can be problematic and may require longer than expected withdrawal periods and may result in withdrawal periods in excess of 3 d.

Solubility in organics

Zilpaterol hydrochloride is very soluble in water and in other aqueous media (about 50% of product dissolved) at different pH values (1–10). It is only slightly soluble in methanol (about 3%) and practically insoluble in most organic solvents (<0.1%) such as ethanol, acetone, ethyl-acetate, isopropyl ether, hexane, toluene, chloroform, dichloromethane or n-octanol.

Properties of Zilpaterol hydrochloride

storage temp.  2-8°C
solubility  DMF: 0.1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
form  neat

Safety information for Zilpaterol hydrochloride

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P314:Get medical advice/attention if you feel unwell.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for Zilpaterol hydrochloride

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