Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listZEBULARINE

ZEBULARINE

Synonym(s):1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside;Zebularine - CAS 3690-10-6 - Calbiochem

  • CAS NO.:3690-10-6
  • Empirical Formula: C9H12N2O5
  • Molecular Weight: 228.2
  • MDL number: MFCD04973699
  • EINECS: 2017-001-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
ZEBULARINE Structural

What is ZEBULARINE?

Description

Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Chemical properties

White Solid

The Uses of ZEBULARINE

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent

The Uses of ZEBULARINE

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

What are the applications of Application

Zebularine is an inhibitor of DNA methyltransferase (Dnmt)

Definition

ChEBI: Zebularine is a member of pyrimidine ribonucleosides.

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Also inhibits cytidine deaminase (K i ~ 2 μ M).

Biochem/physiol Actions

Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

storage

Desiccate at RT

Properties of ZEBULARINE

Melting point: 160-162?C
Boiling point: 499.0±55.0 °C(Predicted)
Density  1.73±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 16 mg/mL, soluble
form  solid
pka 13.48±0.70(Predicted)
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Safety information for ZEBULARINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H320:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for ZEBULARINE

InChIKey RPQZTTQVRYEKCR-WCTZXXKLSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.