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HomeProduct name listZEBULARINE

ZEBULARINE

Synonym(s):1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside;Zebularine - CAS 3690-10-6 - Calbiochem

  • CAS NO.:3690-10-6
  • Empirical Formula: C9H12N2O5
  • Molecular Weight: 228.2
  • MDL number: MFCD04973699
  • EINECS: 2017-001-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
ZEBULARINE Structural

What is ZEBULARINE?

Description

Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Chemical properties

White Solid

The Uses of ZEBULARINE

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent

The Uses of ZEBULARINE

It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

What are the applications of Application

Zebularine is an inhibitor of DNA methyltransferase (Dnmt)

Definition

ChEBI: Zebularine is a member of pyrimidine ribonucleosides.

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC 50 = 120 μ M) and re-activates silenced genes in T24 bladder carcinoma cells. Also inhibits cytidine deaminase (K i ~ 2 μ M).

Biochem/physiol Actions

Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.

storage

Desiccate at RT

Properties of ZEBULARINE

Melting point: 160-162?C
Boiling point: 499.0±55.0 °C(Predicted)
Density  1.73±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 16 mg/mL, soluble
form  solid
pka 13.48±0.70(Predicted)
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Safety information for ZEBULARINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H320:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for ZEBULARINE

InChIKey RPQZTTQVRYEKCR-WCTZXXKLSA-N

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