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HomeProduct name listZ-LEU-LEU-GLU-AMC

Z-LEU-LEU-GLU-AMC

Synonym(s):Cbz-Leu-Leu-Glu-AMC;Z-LLE-AMC

Z-LEU-LEU-GLU-AMC Structural

What is Z-LEU-LEU-GLU-AMC?

Description

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

The Uses of Z-LEU-LEU-GLU-AMC

A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole

The Uses of Z-LEU-LEU-GLU-AMC

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.

What are the applications of Application

Proteasome Substrate II is a fluorogenic substrate for proteosome II

General Description

Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.

Biochem/physiol Actions

Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.

storage

+4°C

Properties of Z-LEU-LEU-GLU-AMC

Boiling point: 967.8±65.0 °C(Predicted)
Density  1.253±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: soluble
form  solid
pka 4.43±0.10(Predicted)
color  Solid lyophilized powder

Safety information for Z-LEU-LEU-GLU-AMC

Computed Descriptors for Z-LEU-LEU-GLU-AMC

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