Z-LEU-LEU-GLU-AMC
Synonym(s):Cbz-Leu-Leu-Glu-AMC;Z-LLE-AMC
- CAS NO.:348086-66-8
- Empirical Formula: C35H44N4O9
- Molecular Weight: 664.75
- MDL number: MFCD01074989
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Z-LEU-LEU-GLU-AMC?
Description
Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.
The Uses of Z-LEU-LEU-GLU-AMC
A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole
The Uses of Z-LEU-LEU-GLU-AMC
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples.
What are the applications of Application
Proteasome Substrate II is a fluorogenic substrate for proteosome II
General Description
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity.
Biochem/physiol Actions
Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.
storage
+4°C
Properties of Z-LEU-LEU-GLU-AMC
Boiling point: | 967.8±65.0 °C(Predicted) |
Density | 1.253±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble |
form | solid |
pka | 4.43±0.10(Predicted) |
color | Solid lyophilized powder |
Safety information for Z-LEU-LEU-GLU-AMC
Computed Descriptors for Z-LEU-LEU-GLU-AMC
New Products
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