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HomeProduct name listZ-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Structural

What is Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE?

Description

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.

The Uses of Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor.

What are the applications of Application

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor

References

1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563

Properties of Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Boiling point: 674.2±55.0 °C(Predicted)
Density  1.440±0.06 g/cm3(Predicted)
storage temp.  −20°C
solubility  Soluble in DMSO (up to 25 mg/ml).
form  White to off-white powder.
pka 4.01±0.19(Predicted)
color  white
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Computed Descriptors for Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

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