AC-DEVD-CHO

Synonym(s):Ac-DEVD-CHO;Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem;CPP32/Apopain Inhibitor, Ac-DEVD-CHO

CAS NO.：169332-60-9
Empirical Formula: C20H30N4O11
Molecular Weight: 502.47
MDL number: MFCD00671412
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

What is AC-DEVD-CHO?

The Uses of AC-DEVD-CHO

Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase

The Uses of AC-DEVD-CHO

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Definition

ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.

General Description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

Properties of AC-DEVD-CHO

Boiling point:	1021.1±65.0 °C(Predicted)
Density	1.374±0.06 g/cm3(Predicted)
RTECS	EK7643000
storage temp.	-20°C
solubility	H₂O: 1 mg/mL
pka	4.19±0.10(Predicted)
form	powder
color	white
Sensitive	Moisture Sensitive

Safety information for AC-DEVD-CHO

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.