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HomeProduct name listYANGONIN

YANGONIN

Synonym(s):4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one

  • CAS NO.:500-62-9
  • Empirical Formula: C15H14O4
  • Molecular Weight: 258.27
  • MDL number: MFCD00221733
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
YANGONIN Structural

What is YANGONIN?

Description

Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 μM. Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 μM, but whether it serves as an agonist or antagonist at this receptor remains to be determined. Yangonin blocks the activation of NF-κB by TNF-α. It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).

The Uses of YANGONIN

A lactone isolated from the Kava plant (Piper methysticum). rokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety d isorders. a supplements.

The Uses of YANGONIN

A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements.

What are the applications of Application

Yangonin is one of the major components of kava extract

Definition

ChEBI: Yangonin is a member of 2-pyranones and an aromatic ether.

Properties of YANGONIN

Melting point: 155-157°
Boiling point: 487.6±45.0 °C(Predicted)
Density  1.325 g/cm3
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
form  neat
color  Pale Yellow to Pale Green
BRN  230710
Stability: Light Sensitive

Safety information for YANGONIN

Computed Descriptors for YANGONIN

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