DIHYDROMETHYSTICIN
Synonym(s):(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one;Dihydromethysticin
- CAS NO.:19902-91-1
- Empirical Formula: C15H16O5
- Molecular Weight: 276.28
- MDL number: MFCD00221731
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
![DIHYDROMETHYSTICIN Structural](https://img.chemicalbook.in/CAS/GIF/19902-91-1.gif)
What is DIHYDROMETHYSTICIN?
Description
Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.
The Uses of DIHYDROMETHYSTICIN
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.
definition
ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether.
Properties of DIHYDROMETHYSTICIN
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
form | neat |
Boiling point: | 476.1±45.0 °C(Predicted) |
Density | 1.28±0.1 g/cm3(Predicted) |
Melting point: | 117-118 °C |
form | Solid |
color | White to Off-White |
BRN | 91699 |
Stability: | Hygroscopic |
Safety information for DIHYDROMETHYSTICIN
Computed Descriptors for DIHYDROMETHYSTICIN
InChIKey | RSIWXFIBHXYNFM-NSHDSACASA-N |
New Products
3-Pyridineacrylic acid 3-Bromo-4-fluorophenol N-Boc-Ethylenediamine cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 4-Aminotetrahydropyran hydrochloride 4,5-Dibromopyridazin-3-one N-Benzyl-3-hydroxypiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-AminophenaethylalcholRelated products of tetrahydrofuran
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