Xanthone

Synonym(s):9-Xanthenone;Xanthone

CAS NO.：90-47-1
Empirical Formula: C13H8O2
Molecular Weight: 196.2
MDL number: MFCD00005060
EINECS: 201-997-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 20:01:59

What is Xanthone?

Description

Xanthone is a compound that has been shown to have a significant cytotoxicity against HL-60 cells and to inhibit the cyclase enzyme. It also inhibits the protein production of mcl-1, which is necessary for the development of cancer cells.

Chemical properties

off-white powder

The Uses of Xanthone

Xanthone is used predominantly as oxygenated polycyclic aromatic compounds, and as a vasorelaxant. It can be used as a fluorescent agent, as well as an intermediate in organic synthesis and chemical research.

The Uses of Xanthone

Acts as an inhibitor of human cancer cell lines.

What are the applications of Application

Xanthone is a predominant oxygenated polycyclic aromatic compounds, vasorelaxant and larvacide

Definition

ChEBI: The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.

Definition

A colorless crystalline organic compound found as a pigment in gentians and other flowers. It is used as an insecticide and in making dyestuffs.

What are the applications of Application

Xanthone has antiinflammatory activity and can be used in treating infectious diseases such as tuberculosis, malaria, and leprosy. The biological properties of it are shown by its ability to scavenge anion radicals and to act as a fluorescence probe for coumarin derivatives.

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 4204, 1972 DOI: 10.1021/jo00798a059

Purification Methods

It has also been recrystallised from n-hexane three times and sublimed in vacuo. [Saltiel J Am Chem Soc 108 2674 1986]. [Beilstein 17 H 354, 17 I 190, 17 II 378, 17 III/IV 5292, 17/10 V 430.]

Properties of Xanthone

Melting point:	172-174 °C(lit.)
Boiling point:	349-350 °C730 mm Hg(lit.)
Density	1.1607 (rough estimate)
refractive index	1.6000 (estimate)
Flash point:	350-351°C
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Solid
form	neat
color	White to Light Purple
Water Solubility	It is Soluble in water (partly), chloroform, hot Toluene, ether (slightly), and hot alcohol.
Merck	14,10062
BRN	140443
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	90-47-1(CAS DataBase Reference)
NIST Chemistry Reference	Xanthone(90-47-1)
EPA Substance Registry System	9H-Xanthen-9-one (90-47-1)

Safety information for Xanthone

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.