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HomeProduct name listWP631

WP631

  • Empirical Formula: C62H66Cl2N2O20
  • Molecular Weight: 1230.09
  • MDL number: MFCD08061905
  • Update Date: 2023-04-23 13:52:06
WP631 Structural

What is WP631?

Description

WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4? Abrogates HIV-1 replication via inhibition of Tat transactivation.5

References

Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402 Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584 Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273 Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86 Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652

Properties of WP631

storage temp.  -20°C (des,)
solubility  Soluble in DMSO (up to 5 mg/ml)
form  solid
color  Red
Stability: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety information for WP631

Computed Descriptors for WP631

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