WP631
- Empirical Formula: C62H66Cl2N2O20
- Molecular Weight: 1230.09
- MDL number: MFCD08061905
- Update Date: 2023-04-23 13:52:06
What is WP631?
Description
WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4? Abrogates HIV-1 replication via inhibition of Tat transactivation.5
References
Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402 Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584 Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273 Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86 Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652
Properties of WP631
storage temp. | -20°C (des,) |
solubility | Soluble in DMSO (up to 5 mg/ml) |
form | solid |
color | Red |
Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for WP631
Computed Descriptors for WP631
New Products
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