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HomeProduct name listETHAMIVAN

ETHAMIVAN

  • CAS NO.:304-84-7
  • Empirical Formula: C12H17NO3
  • Molecular Weight: 223.27
  • MDL number: MFCD00026727
  • EINECS: 206-157-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:54:58
ETHAMIVAN Structural

What is ETHAMIVAN?

Originator

Emivan,U.S.V.,US,1961

The Uses of ETHAMIVAN

antihypertensive, vasoconstrictor

The Uses of ETHAMIVAN

Vanillic acid diethylamide is a central nervous system and respiratory stimulant.

What are the applications of Application

Vanillic acid diethylamide is a central nervous system and respiratory stimulant

Definition

ChEBI: Etamivan is phenol substituted at C-2 and C-4 by a methoxy group and an N,N-diethylaminocarbonyl group respectively. A respiratory stimulant drug related to nikethamide, it has now fallen largely into disuse. It is a member of phenols and a member of methoxybenzenes.

Manufacturing Process

4 g of vanillinic acid are mixed with 3.6 g of diethylamine, after cooling 2.2 g of phosphorus pentoxide and the same amount of glass powder are added, and then reacted with xylene until a thin paste has been formed. The latter is boiled for some hours in the reflux cooler, moisture being excluded. Decantation follows, and the residue is dissolved by means of a warm solution of potassium carbonate until only glass powder or small amount of impurities remain undissolved, and then the xylene solution is shaken up therewith, The xylene solution is then separated, the aqueous layer is again extracted with ether, and the ether extract is combined with the xylene solution. The mixture is then distilled under the lowest possible pressure, collecting the fraction between 170°C and 250°C (referred to 10 Torr), and purifying it by further fractionation. In this way a slightly yellowish oil is obtained, which crystallizes after some time. By dissolving in ligroin and crystallizing, pure vanillinic acid diethylamide is obtained in the form of white needles; MP 95°C to 95.5°C.

brand name

Vandid (3M Pharmaceuticals).

Therapeutic Function

Central and respiratory stimulant

World Health Organization (WHO)

Etamivan is a central and respiratory stimulant.

Properties of ETHAMIVAN

Melting point: 96-97 °C
Boiling point: 364.56°C (rough estimate)
Density  1.1223 (rough estimate)
refractive index  1.5300 (estimate)
storage temp.  Store at -20°C
solubility  methanol: 0.1 g/mL, clear
pka 8.73±0.20(Predicted)
form  A solid
color  White to off-white
Merck  13,3756
CAS DataBase Reference 304-84-7

Safety information for ETHAMIVAN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for ETHAMIVAN

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