Valethamate bromide
- CAS NO.:90-22-2
- Empirical Formula: C19H32BrNO2
- Molecular Weight: 386.37
- MDL number: MFCD00031617
- EINECS: 201-977-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Valethamate bromide?
Originator
Murel,Ayerst,US
Definition
ChEBI: Valethamate bromide is an alkylbenzene.
Manufacturing Process
Benzyl cyanide is first reacted with 2-butylbromide in the presence of sodium amide to give 2-phenyl-3-methylvaleronitrile which is hydrolyzed by sulfuric acid to give 3-methyl-2-phenylpentanoic acid. 24 g of 2-phenyl-3- methylpentanoic acid are heated for one hour at 175° to 185°C with 30 g of 2-diethylaminoethanol and 0.5 g of sodium methylate. The excess diethylaminoethanol is removed in vacuo, the residue is dissolved in 300 cc of 2 N-acetic acid, the acid solution is shaken with ether and made alkaline with concentrated potassium carbonate solution and ice. The ether solution is washed with water, dried with sodium sulfate and evaporated. The residue is distilled under high vacuum, yielding 20 to 21 g of the basic ester (60% of the theoretical) is obtained, the ester boiling at 98° to 100°C at a pressure of 0.03 mm. The hydrochloride of the ester melts at 112°to 113°C and the methobromide at 100° to 101°C.
Therapeutic Function
Anticholinergic
Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. See also ESTERS and BROMIDES. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Br-.
Properties of Valethamate bromide
Melting point: | 120-127℃ |
RTECS | BP7600000 |
storage temp. | Inert atmosphere,Room Temperature |
Water Solubility | almost transparency in Water |
solubility | DMSO : 100 mg/mL (258.82 mM; Need ultrasonic) |
form | Powder |
color | White to Almost white |
Merck | 14,9906 |
CAS DataBase Reference | 90-22-2(CAS DataBase Reference) |
Safety information for Valethamate bromide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Valethamate bromide
Abamectin manufacturer
Flowchem Pharma Pvt Ltd
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