URSODEOXYCHOLIC-2,2,4,4-D4 ACID
- CAS NO.：347841-46-7
- Empirical Formula: C24H40O4
- Molecular Weight: 392.58
- MDL number: MFCD01317390
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is URSODEOXYCHOLIC-2,2,4,4-D4 ACID?
Description
Ursodeoxycholic acid-d4 (UDCA-d4) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
The Uses of URSODEOXYCHOLIC-2,2,4,4-D4 ACID
Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.
Properties of URSODEOXYCHOLIC-2,2,4,4-D4 ACID
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for URSODEOXYCHOLIC-2,2,4,4-D4 ACID
Computed Descriptors for URSODEOXYCHOLIC-2,2,4,4-D4 ACID
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