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HomeProduct name listURSODEOXYCHOLIC-2,2,4,4-D4 ACID

URSODEOXYCHOLIC-2,2,4,4-D4 ACID

URSODEOXYCHOLIC-2,2,4,4-D4 ACID Structural

What is URSODEOXYCHOLIC-2,2,4,4-D4 ACID?

Description

Ursodeoxycholic acid-d4 (UDCA-d4) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.

The Uses of URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.

Properties of URSODEOXYCHOLIC-2,2,4,4-D4 ACID

storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly),
form  Solid
color  White to Off-White
Stability: Hygroscopic

Safety information for URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Computed Descriptors for URSODEOXYCHOLIC-2,2,4,4-D4 ACID

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