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HomeProduct name listURICASE

URICASE

Synonym(s):Urate oxidase;Urate: oxygen oxoreductase;Urate:O2 oxidoreductase

  • CAS NO.:9002-12-4
  • Empirical Formula: C18H26N5O14P
  • Molecular Weight: 567.397901
  • MDL number: MFCD00082126
  • EINECS: 232-655-5
  • Update Date: 2024-10-28 16:48:35
URICASE Structural

What is URICASE?

Chemical properties

White powder

The Uses of URICASE

Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.

The Uses of URICASE

In the determination of serum and urine uric acid.

The Uses of URICASE

Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.

General Description

Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.

Biochem/physiol Actions

Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .

Properties of URICASE

storage temp.  -20°C
form  lyophilized powder
color  White to off-white
Water Solubility  Hardly soluble in water, slightly soluble in buffer alkaline solution.
Merck  13,9944
EPA Substance Registry System Oxidase, urate (9002-12-4)

Safety information for URICASE

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H319:Serious eye damage/eye irritation
H334:Sensitisation, respiratory
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for URICASE

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